pentobarbital will reduce the extent or outcome of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in clients who are chronically making use of a robust CYP3A4 inducer
buprenorphine subdermal implant and pentobarbital both boost sedation. Stay clear of or Use Alternate Drug. Limit use to individuals for whom alternate therapy possibilities are insufficient
pentobarbital will decrease the extent or outcome of nisoldipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or effect of eletriptan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Caution when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone might maximize and may lead to probably lethal respiratory despair
Contraindicated (1)pentobarbital will reduce the extent or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women mustn't select estradiol valerate/dienogest as their contraceptive even though making use of strong CYP3A4 inducers as a result of likely reduce in contraceptive efficacy.
pentobarbital will decrease the extent or result of diltiazem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or impact of fosphenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.
pentobarbital and olopatadine intranasal each maximize sedation. Prevent or Use Alternate Drug. Coadministration will increase risk of CNS melancholy, which can lead to additive impairment of psychomotor effectiveness and trigger daytime impairment.
pentobarbital will lessen the extent or effect of levoketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
pentobarbital will decrease the extent or impact of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Double brexpiprazole dose in excess of 1-two weeks if administered with a robust CYP3A4 inducer.
pentobarbital will minimize the level or result of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
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