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pentobarbital will reduce the extent or outcome of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in clients who are chronically making use of a robust CYP3A4 inducerbuprenorphine subdermal implant and pentobarbital b

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